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Pfizer is to set up a £41m stem cell research centre at Granta science park in Cambridge, employing about 40 researchers.
Pfizer is to acquire PowderMed, the Oxford-based DNA vaccines company, for up to £214m.
Pfizer is to acquire Meridica, the Cambridge-based drug delivery company, from PA Consulting for £70m.
Pfizer is to close its sales and marketing office in Southampton in March with the loss of up to 115 jobs, while a further 60 staff will relocate to its headquarters in Surrey.
Pfizer is to close the Pharmacia drug development centre in High Wycombe with the loss of 164 jobs, although some jobs will be relocated to its site in Kent.
Pfizer has confirmed plans to relocate a major part of its sales and marketing operation from Sandwich to Walton-on-the-Hill, near Tadworth, in December, where it will initially employ 425 staff.
Pfizer has announced plans to build a £134m pharmaceuticals research centre at Sandwich in Kent, with the creation of 400 jobs.
Pfizer is to close its laboratories at Addenbrooke's Hospital in Cambridge this year, in order to relocate 100 scientists to its research campus in Kent.
Pfizer has reached agreement to acquire Warner-Lambert for $90bn, in order to create the second largest pharmaceuticals group in the world.
Pfizer has awarded a contract to Laing for the construction of a £50m information technology headquarters in Tadworth, Surrey, where it will employ about 900 people.
Pfizer, the US healthcare company, is planning to set up a European headquarters in Reigate which will employ 900 people.
Pfizer of the US is planning to invest £110m on the expansion of its pharmaceuticals site at Sandwich, Kent, creating 1,000 jobs.