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Novartis is to set up a new 64,000 sq ft headquarters for its pharmaceuticals business at Watchmoor Park in Camberley next March.
Novartis is hoping to win government support to upgrade its vaccines plant in Speke within five years, in order to secure the future of 750 jobs.
Novartis is to submit plans for the £4.5m development of three wind turbines at its Humber Bank site.
Novartis has confirmed plans to build a major new pharmaceuticals production plant in Grimsby to manufacture ingredients for the Diovan treatment for high blood pressure, and construction is expected to start next year.
Novartis is planning to invest £34m at its Grimsby pharmaceuticals plant to manufacture the intermediates for the new Cox 189 pain relief drug.
Novartis has opened a £40m research centre in Horsham to develop treatments for respiratory diseases, and the site will employ 180 scientists.