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Angel Biotechnology, the Midlothian-based biotech firm with 22 staff, has gone into administration through KPMG. 11-Feb-2013

Altrika, the Sheffield-based biotechnology firm, has been sold by Ilika to Adiposet for £0.1m. 31-Dec-2012

Infinergy Technology is seeking permission to build a £16m biotechnology-based power station at Ricall Business Park in Selby, with the creation of 36 jobs. 11-Oct-2012

F2G has secured £19m from Advent Life Sciences and Novartis Bioventures to fund the expansion of its Manchester-based biotechnology business. 06-Sep-2012

Plant Impact is to relocate the headquarters of its biotechnology business from Preston to its Rothamsted research centre in Hertfordshire in September. 17-Jul-2012

PsiOxus Therapeutics has secured a £22m investment from Imperial Innovations and others to fund the expansion of its Oxford-based biotechnology business. 10-Jul-2012

Proximagen, the biotechnology firm with 40 staff in London and Cambridge, is to be acquired by US-based Upsher-Smith for at least £223m. 14-Jun-2012

Vitrology, the Glasgow-based biotechnology firm with 38 staff, is to be acquired by SGS of Switzerland. 22-May-2012

Pharmacells has bought the assets of Immunosolv, the Edinburgh-based biotechnology firm, out of liquidation. 17-Apr-2012

Ingenza is to create up to 40 jobs at its new biotech laboratory at the Roslin BioCentre in Midlothian. 03-Apr-2012

Verona Pharma has raised £3.2m in a share placing to fund the expansion of its London-based biotechnology business. 12-Dec-2011

Horizon Discovery has raised £11m from investors to fund the expansion of its Cambridge-based biotechnology business. 19-Sep-2011

E-Therapeutics is to create about ten jobs at a new biotechnology research facility in Oxford by October. 01-Aug-2011

Q Chip has raised a further £3.6m from investors to fund the expansion of its Cardiff-based biotechnology business. 14-Jun-2011

Oxford Nanopore Technologies has raised £25m in a share placing to fund improvements to its biotechnology production facilities. 04-May-2011

Binding Site, the Birmingham-based biotechnology company, has been acquired by private equity firm Nordic Capital for undisclosed terms. 27-Apr-2011

Chirotech is looking to increase the 40-strong workforce at its newly-expanded 33,000 sq ft biotechnology facility at Cambridge Science Park. 12-Apr-2011

Randox Laboratories is to invest £16m in the expansion of its biotechnology facilities in Antrim, with the creation of 242 jobs. 21-Mar-2011

MSD Biologics, the Billingham-based biotechnology firm with 480 staff, is to be acquired by Fujifilm of Japan, as part of a £300m deal that also includes US-based Diosynth RTP. 03-Mar-2011

EnviroGene, the Caerphilly-based supplier of biotechnology products to the water and oil industries, has gone into administration through PricewaterhouseCoopers. 10-Jan-2011

PsiOxus Therapeutics has announced the formation of a new Oxfordshire-based biotechnology group from the merger of Myotec Therapeutics with Hybrid Biosystems. 15-Dec-2010

Gen-Probe, the US biotechnology company, is to set up a £5m European headquarters in Manchester, extending its current site in Wythenshawe from 11,000 sq ft to 60,000 sq ft and creating 35 new jobs by 2012. 15-Nov-2010

Horizon Discovery has secured £6.2m of venture capital funding to expand its Cambridge-based biotechnology business. 29-Sep-2010

Henderson Morley, the Birmingham-based biotechnology firm, is expected to go into administration. 31-Aug-2010

Reinnervate has secured about £1.6m of venture capital funding to expand its Durham-based cell culture biotechnology business. 01-Jun-2010

Aquapharm Biodiscovery has raised £4.2m from investors to fund the expansion of its Oban-based marine biotechnology business. 29-Mar-2010

Centre for Process Innovation is to create up to 40 jobs at a new £12m industrial biotechnology testing centre due to open at Wilton on Teesside later this year. 15-Mar-2010

Avecia Biologics, the Billingham-based biotechnology company with 500 staff, is to be acquired by Merck for undisclosed terms. 21-Dec-2009

Silence Therapeutics is to acquire Intradigm, the US biotechnology company specialising in experimental medicines based on RNA interference, for £16m. 17-Dec-2009

Scottish Enterprise has announced government funding of £24m for the development of a "bioincubator" in Edinburgh's BioQuarter, in order to create up to 200 jobs in the biotechnology sector over the next five years. 10-Dec-2009

Epistem is to raise £2.9m in a share placing to fund the expansion of its Manchester-based biotechnology business. 23-Nov-2009

New Horizons Global is planning to expand the 18-strong workforce at its biotechnology operation in Knowsley to 60 over the next year, following a £1.4m investment in the production of omega-3 oil. 08-Oct-2009

Provexis is in discussions to raise £5m from investors to fund the expansion of its biotechnology operations in Windsor and Liverpool. 24-Sep-2009

Excalibur has acquired International Biosciences Managers, the biotechnology advisory and fund management firm, for undisclosed terms. 21-Sep-2009

Renovo is planning to shed up to one third of the 180 jobs at its Manchester-based biotechnology business, in order to focus on the development of anti-scarring drugs. 21-Sep-2009

Randox Laboratories is to create a further 34 jobs at its biotechnology business in County Antrim. 14-Sep-2009

The Department for Business Innovation & Skills is to invest £12m in a new industrial biotechnology demonstrator facility at Wilton on Teesside by next year, with the creation of up to 40 jobs. 20-Jul-2009

Genzyme is to expand the 100-strong workforce at its Oxford-based biotechnology business with ten new jobs, having agreed a strategic partnership with Bayer. 02-Apr-2009

BioVex, the biotechnology company with offices in Oxford and the US, has raised a further £30m of capital to expand its business. 30-Mar-2009

Oxford Gene Technology has acquired Sense Proteomic, the Maidenhead-based biotechnology firm with eight staff, taking its total workforce to more than 50. 19-Mar-2009

DxS is planning to expand the 60-strong workforce at its Manchester-based biotechnology business with 20 additional scientists and support staff this year. 23-Feb-2009

Phytopharm is to shed 15 of the 40 jobs at its biotechnology research business in Godmanchester. 19-Feb-2009

Avacta Group is to acquire Curidium Medica, the London-based biotechnology and diagnostics firm, for about £6.2m. 12-Jan-2009

GE Healthcare is to stop production of radiochemicals at its site in Cardiff over the next 18 months, with the loss of up to 155 of the 420 jobs, but 150 biotechnology research jobs will be created. 18-Dec-2008

York Pharma has bought the assets of Celltran, the Sheffield-based biotechnology company with two wound care products, out of administration. 29-Oct-2008

Aquapharm is looking to raise a further £4m to fund the expansion of its Scottish biotechnology business, and hopes to agree a commercial licensing deal to develop anti-dandruff shampoos from marine microbes. 28-Oct-2008

Apitope, the Bristol-based biotechnology company, is to transfer its headquarters to Belgium, having secured a £7.7m funding package from a group of investors in Belgium and Luxembourg. 22-Oct-2008

Protherics, the biotechnology company with 300 staff at sites in Runcorn, London, Ceredigion, Australia and the US, is to be acquired by BTG for £218m. 19-Sep-2008

Cyclacel is to shed 17 jobs at its biotechnology research operation in Dundee, and its Cambridge site will close with the loss of seven jobs. 19-Sep-2008

Cellzome, the biotechnology company with 95 staff in Cambridge and Germany, has agreed a deal worth up to £800m with GlaxoSmithKline to develop pharmaceuticals for inflammatory diseases. 11-Sep-2008

Shire is to acquire Jerini, the German biotechnology company, for £260m, in order to expand its genetic therapy business. 07-Jul-2008

Ardana, the Edinburgh-based biotechnology company, has gone into voluntary administration through Ernst & Young, having failed to find a buyer. 01-Jul-2008

CellTran, the biotechnology company that develops skin treatments for burns, has gone into administration with the loss of half of the 12 jobs. 17-Jun-2008

Piramed, the Slough-based biotechnology company, is to be acquired by Roche of Switzerland for £90m. 15-Apr-2008

Myconostica of Manchester has raised £3.9m of venture capital to fund the commercial development of its biotechnology-based diagnostic products. 09-Apr-2008

EUSA Pharma of Oxford has acquired Cytogen, the US biotechnology firm, for £11m, taking its worldwide workforce to more than 200. 13-Mar-2008

Antisoma, the biotechnology company, is to set up a 15,000 sq ft office at Chiswick Park in West London in May. 04-Mar-2008

Illumina, the US biotechnology company, is to set up a new 41,500 sq ft European headquarters at Chesterford Research Park in Essex. 26-Feb-2008

Vernalis is to shed 120 of the 210 jobs at its Wokingham-based biotechnology business, in order to focus on research and development. 21-Feb-2008

Siemens Healthcare Diagnostics is to expand its biotechnology products factory in Llanberis, Gwynedd, with the creation of up to 200 jobs over the next two years. 06-Feb-2008

AstraZeneca is to acquire MedImmune, the US biotechnology company that is developing about 45 experimental drugs and flu vaccines and has almost 3,000 staff, for £7.7bn. 24-Apr-2007

Gentronix has secured a £1.4m investment from NVM Private Equity and existing backers to fund the recruitment of a global sales team for its Manchester-based biotechnology business. 19-Mar-2007

Hays has acquired James Harvard, the London-based recruitment company specialising in the pharmaceutical and biotechnology sectors, for an initial £24m. 28-Feb-2007

AstraZeneca is to acquire Arrow Therapeutics, the London-based biotechnology company with 57 staff, for £76m, and has also announced plans to shed 3,000 jobs over the next three years. 02-Feb-2007

Cellartis of Sweden is planning to set up a £9m biotechnology research centre in Dundee, with the creation of up to 75 jobs. 19-Jan-2007

Protherics has raised £38m in a share placing to fund the expansion of its biotechnology business, including the acquisition of US-based MacroMed and licensing deals with Glenveigh Pharmaceuticals and Advanced In Vitro Cell Technologies. 05-Jan-2007

Evolutec, the Reading-based biotechnology company, has put itself up for sale. 04-Jan-2007

GlaxoSmithKline is to acquire Domantis, the Cambridge-based biotechnology research company, for £230m. 11-Dec-2006

Ixico of London has raised £0.9m to fund the commercial development of drug discovery software for the biotechnology industry. 07-Aug-2006

Premier Research Group has acquired Scirex Corporation, the US-based provider of outsourced clinical services to the biotechnology and pharmaceutical industries with offices in London and Poland, for £16m. 11-Jul-2006

NeuTec Pharma, the Manchester-based biotechnology company, has received a £305m takeover approach from Novartis of Switzerland. 07-Jun-2006

AstraZeneca is to acquire Cambridge Antibody Technology, the Cambridge-based biotechnology company with 300 staff, for £700m. 15-May-2006

Ark Therapeutics has announced plans to raise £25m in a share placing to fund the commercial development of its biotechnology-based products. 28-Apr-2006

Protherics, the biotechnology company developing a new treatment for sepsis, is to invest £10m in research this year. 10-Apr-2006

Stem Cell Sciences, the Edinburgh-based biotechnology company, is planning to set up an automated cell-production facility in Cambridge and a sales office in California. 03-Apr-2006

Renovo is reviving plans to raise up to £40m in a flotation to fund the development of its Manchester-based biotechnology business. 06-Mar-2006

Amgen of the US is planning to expand its UK-based biotechnology operations over the next ten years, with a £100m investment at sites in Uxbridge and Cambridge. 25-Jan-2006

GlaxoSmithKline is considering plans to launch a takeover bid for Serono, the Swiss biotechnology company valued at £6.8bn. 12-Jan-2006

AstraZeneca is planning to acquire KuDOS Pharmaceuticals, the biotechnology company with 75 staff in Cambridge and Horsham, for £121m. 28-Dec-2005

XenoSense, the Belfast-based biotechnology company with seven staff, has been acquired by Biacore International of Sweden. 17-Nov-2005

Pharmagene, the biotechnology company, has agreed terms for a £13m merger with Asterand of the US, which is expected to lead to the loss of about 23 jobs. 20-Sep-2005

Pro2Kem has closed its biotechnology operation in Dundee, with the loss of the remaining five staff. 12-Aug-2005

Intercytex has raised £12m to fund the commercial development of its biotechnology business, including the ICX-Pro wound healing product. 08-Aug-2005

Shire is planning to acquire Transkaryotic Therapies, the US biotechnology company, for about £920m. 28-Jul-2005

Quay Pharmaceuticals is planning to relocate its biotechnology business from Bromborough to a 22,000 sq ft laboratory at the Estuary Commerce Park in Speke next year, and the workforce is expected to rise from 20 to 84. 14-Jul-2005

Vernalis is to acquire Ionix Pharmaceuticals, the Cambridge-based biotechnology company, for £12m. 07-Jul-2005

SR Pharma is planning to acquire Atugen, the German biotechnology company with 30 staff, in a reverse takeover. 22-Jun-2005

Shire Pharmaceuticals is to acquire Transkaryotic Therapies, the US biotechnology company that produces drugs for genetic disorders, for £839m. 25-Apr-2005

Avecia is to close its biotechnology laboratory at Grangemouth this summer, with the loss of 95 jobs. 11-Apr-2005

Vernalis, the biotechnology company, is raising £30m in a share placing to strengthen its balance sheet and establish a sales force in the US. 28-Feb-2005

ProPharma is planning to double the workforce at its Glasgow-based biotechnology business to 60 over the next three years. 01-Dec-2004

CellFactors, the Cambridge-based biotechnology company, has gone into administration. 02-Aug-2004

Ardana, the Edinburgh-based biotechnology company, has secured £9m of new funding to expand its sales and marketing operations and to pursue further licensing opportunities. 28-May-2004

Profile Therapeutics, the West Sussex-based biotechnology company, is to be acquired by Respironics of the US for £25m. 24-May-2004

Celltech, the biotechnology company, is to be acquired by UCB of Belgium for £1.53bn. 19-May-2004

Amersham, the biotechnology and medical imaging company, is expected to shed up to 100 jobs in Buckinghamshire over the next 12 months, following its acquisition by GE. 30-Apr-2004

Orla Protein Technologies has secured a £0.3m grant from Northern Enterprise to expand its nanobiotechnology business and collaborate with global pharmaceutical groups. 17-Feb-2004

Accelrys is creating 30 new jobs at its biotechnology software business in Cambridge. 12-Feb-2004

Ark Therapeutics, the biotechnology group, is considering plans for a flotation with a valuation of more than £100m. 09-Feb-2004

Acambis is to close its vaccine research centre in Cambridge with the loss of 40 jobs, in order to focus its biotechnology research activities in the US. 02-Feb-2004